Supramolecular regulation of tumor microenvironment and tumor metabolism for cancer immunotherapy.

The tumor microenvironment, the network of immune cells, tumor cells, stromal cells and the extracellular matrix, always promotes tumor angiogenesis and favors tumor immune tolerance by hampering the infiltration and priming of effector lymphocytes. Tumor bed is also considered as a metabolic desert where T cells suffer from persistent nutrition deficiency stress. Oncogene-driven changes in tumor cell metabolism can impact the tumor microenvironment to limit immune responses and present barriers to cancer therapy. We are interested in the development of new supramolecular systems that can be specifically accumulated in tumors to regulate tumor microenvironment and manipulate the metabolism of cancer cells and lymphocytes, thus reshaping the immunological landscape and reinvigorating anti-tumor immunity.


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