Our paper was accepted by Angew!


Liposomes  and  polymersomes,   typical  vesicular  drug  delivery  systems  (DDSs),  have  faced  some  limitations  in  cancer  theranostics. Suprasomes,   supramolecular   vesicles   assembled   from amphiphiles linked by noncovalent interactions, show potential as  new  generation  of vesicular  DDSs.  We  construct  suprasomesbased  on  host–guest  recognition,  by  which  the  desired  functions  can    be    integrated    into    carriers    without    tedious    synthesis.    Photothermally  active  host–guest  complex  is  formed  between  a functional  guest and  pillar[5]arene, which  further  self-assembles into hollow   suprasomes. A   supramolecular   nanomedicine   is   developed   by   encapsulating   cisplatin   in   the   suprasomes.   The   obtained    cisplatin@Suprasomes    achieve    excellent    anticancer    efficacy    and    anti-metastasiscombining    chemotherapy    and    photothermal therapy, which ablate the tumors without relapse and metastasis.  This  work  demonstrates  the  facile  functionalization  of  suprasomes,  holding  promise  as  alternatives  to  liposomes  and  polymersomes.


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